D'Souza's comments are beyond the pale, and bloggers across the political spectrum have ripped Dinesh. However, the best response comes from a diary over at Daily Kos. An atheist and professor at V.T. responded with some fantastic remarks which can be read here.
I should say that I'm not an atheist. I was raised a Christian, and am still one at least in name, but I can say I am far more sympathetic to the views of agnostics and atheists than I have ever been previously. Along those lines, I want to highlight a particular comment from the Kos diary. The author writes:
I don’t need to live forever to live once and to live completely.
That's some powerful stuff and worth remembering.